7. Adapt to Map Mods and Boss Mechanics
Certain map mods and boss mechanics introduce immunity or resistance to specific ailments. Adapting to these situations can make encounters much smoother:

Map Mods: If you’re running maps with modifiers like "Monsters cannot be Ignited," "Cannot be Frozen," or "Monsters have x% chance to avoid elemental ailments," switch to a more direct-damage playstyle for that map. Using flasks that boost raw damage or DoT effects is helpful in these situations.

Boss Mechanics: Many endgame bosses (Shaper, Sirus, Uber Elder) are immune to Path of exile currency Freeze, Shock, and Ignite. For these encounters, it's crucial to optimize your build to deal raw damage or scale other effects like physical DoT or chaos damage.

Conclusion
Overcoming ailment immunity in Path of Exile requires flexibility in buy POE orbs build design and strategy. By incorporating alternative damage sources, increasing ailment effectiveness, using specialized items, and adapting to specific map and boss mechanics, you can still deal significant damage and succeed even when ailments like Ignite, Freeze, or Shock are neutralized.