After Gaining Better Gear:

Once you acquire high-quality gear or unique items, it’s a good time to raise the difficulty. This allows you to maximize the potential of your character while facing tougher enemies.
If You’re Finding Content Too Easy:

If you notice that enemies are falling quickly and Diablo 4 Items combat feels unchallenging, it may be time to increase the difficulty level for a more engaging experience.
Engaging in Endgame Content:

In endgame modes like Nightmare Dungeons, Helltides, and Torment difficulties, you’ll want to adjust the World Tier to ensure you’re receiving adequate challenges and rewards, especially when pursuing rare loot.
During Community Events or Seasonal Activities:

When participating in community events or seasonal content, assess your performance and the rewards. If the content feels too easy, increase the difficulty to Diablo 4 Items for sale enhance your experience.